Program MCTW
Thursday 10th of October 2024
SESSION I – BASIC RESEARCH IN MULTIPLE MYELOMA
Chair: Assoc. Prof. Michal Šimíček, PhD
09:40 Composition of Bone Marrow Adipose Tissue in Multiple Myeloma
Patients
Zoltán
Kellermayer, MD, PhD – Institute of Immunology and
Biotechnology, University of Pécs, HU
09:55 Topic2 – TBD
Narendra
Varma Gottumukkala, MSc – Central European Institute of Technology (CEITEC), Masaryk University,
Brno, CZ
10:10 Development of novel anti-SEM4A allogenic CAR T-cells
Assoc. Prof. Michal Šimíček, PhD – Blood Cancer Research Group, Ostrava, CZ
SESSION II – ACADEMIC APPROACH TO CAR T THERAPY
Chair: Prof. Roman Hájek, MD, PhD
10:45 Academic approach to CAR-T therapy – Spain experience
Dr. Natalia Tovar – Hospital Clínic de Barcelona, ES
11:00 Update to The Role
of Allogeneic Hematopoietic Cell Transplantation in Multiple Myeloma in
Poland
Prof. Sebastian Giebel, MD, PhD – Maria Skłodowska-Curie Memorial Cancer Centre and Institute of
Oncology, Gliwice, PL
11:15 Academic approach to CAR-T therapy in the Czech Republic
Assoc. Prof. Pavel Otáhal, MD, PhD – Institute of Hematology and Blood Transfusion, Prague, CZ
11:30 Development of Allogenic Cell Therapy in OstravaAssoc. Prof. Michal Šimíček, PhD – Blood Cancer Research Group, Ostrava, CZ
SESSION III – PREDICTORS OF TREATMENT RESPONSE IN IMMUNOTHERAPY – CAN WE MOVE ON?
Chair: Jana Mihályová, MD
13:00 The Ideal Sequence of T-Cell Engaging Therapies
Maximilian Merz, MD, PD – Department for Hematology, Cell Therapy and Hemostaseology, University Hospital of Leipzig, DE
13:15 Monitoring of anti-BCMA CAR-T cells
and non-CAR-T immune subsets in multiple myeloma patients
Ondřej Venglář, PhD – Blood Cancer Research Group, Ostrava, CZ
13:30 Identifying and Overcoming
Mechanisms of Resistance in Multiple Myeloma Patients Receiving Talquetamab
Tarek H. Mouhieddine, MD (online) – Tisch Cancer Institute, Icahn School of
Medicine at Mount Sinai, New York, NY, USA
13:45 Single Cell Immune Profiling in Patients Undergoing BCMA Therapy
Junia Vieira dos Santos, MD, PhD (online) – Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
SESSION IV – FUTURE PERSPECTIVES IN CAR T-CELL THERAPY
Chair: Piotr Celichowski, PhD
14:05 Development of CAR T-Cells Therapy
from Stem Cells
Maria Themeli, MD, PhD (online) – Department of Hematology, Amsterdam UMC, NL
14:20 Development of Nanobodies and Nanobody
Based CARs
Prof. Elzbieta Sarnowska, PhD – Maria Skłodowska-Curie National Research Institute of Oncology, PL
Topic3 – to be clarified (Chimeric TCR for MM)Sylvain Simon, PhD (online) – Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Topic4 – TBD
Piotr Celichowski – Blood Cancer Research Group, Ostrava, CZ
SESSION V – NEW PERSPECTIVES ON RARE MONOCLONAL GAMMOPATHIES
Chair: Zuzana Chyra, PhD / Tereza Popková, MD
15:25 Highly efficient genome editing in
pluripotent stem cells under GMP-compatible conditions and differentiation into
Monocytes/Macrophages
Ruba Hammad, MSc (online) – Institute for Transfusion Medicine and Gene Therapy, University of
Freiburg, DE
15:40 Engineering Cells for Cancer
Immunotherapy
Quanyin Hu, PhD (online) – Wisconsin Center for NanoBioSystems, University of Wisconsin, Madison,
USA
15:55 Topic3 – TBD
Dr. Nicolò Danesin (?) - Hematology Unit, University
of Padua, Italy
Topic4 – TBD
name surname – institute
Friday 11th of October 2024
SESSION VI – CHALLENGES IN BIOINFORMATICS
Chair: David Žihala, PhD
09:30Unraveling the Diversity and Functions of Tissue-Resident Plasma CellsProf. Stephen L. Nutt, PhD (online) – The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, AU
09:45 Resolving the Spatial Architecture of Myeloma and Its Microenvironment at the Single-Cell Level
Prof. Niels Weinhold, PhD – Heidelberg Myeloma Center, Department of Medicine, University Hospital Heidelberg, Heidelberg, DE
10:00 Single cell RNA sequencing to
identify circulating tumor cells
Romanos Sklavenitis-Pistofidis, MD, PhD (online) – Dana-Farber Cancer Institute, Harvard
Medical School, Boston, MA, USA
10:15 Dissecting the multicellular
ecosystem in extramedullary myeloma using spatial transcriptomics
Moutaz Helal, MSc – University Hospital of Würzburg, Würzburg, DE
10:30 Composition and
fitness of T and NK cells in extramedullary myeloma tumor microenvironment
Anjana Sithara
Anilkumar, MSc – Blood Cancer Research
Group, Ostrava, CZ